Accolate works by directly blocking substances called leukotrienes, which are molecules that contribute to inflammation and narrowing in the airways, a process that leads to symptoms such as difficulty in breathing in patients with asthma. The action of Accolate reduces this inflammation and thus helps to control the symptoms of asthma, and improves lung function.Even if symptoms are not present, you should keep taking Accolate so it can continue to block the leukotrienes and help give you more control of potential asthma symptoms.